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KMID : 0358420080510090974
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 9 p.974 ~ p.981
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Expression of Wnt 1 and β-catenin in epithelial ovarian cancer
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Yim Kyoung-Ran
Jeong Sang-Geun
Lee Cahn
Oh Yei-Eun
Kim Yong-Min
Kim Kwang-Il
Kim Seung-Jo
Hwang Youn-Yeung
Lee Seon-Young
Na Young-Jeong
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Abstract
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Objective: We were trying to identify the expression of Wnt 1 and β-catenin in normal ovarian epithelium and epithelial ovarian tumor.
Methods: We used archival formalin-fixed and paraffin-embedded tissues from Comprehensive Gynecologic Cancer Center and the Department of Pathology at Bundang CHA Hospital from 2000 to 2005. Immunohistochemical staining for Wnt 1 and β-catenin was performed on the ovarian epithelial tissues. Statistical analyses were performed with SPSS 10.1 for Windows and significance was defined as P<0.05.
Results: Of 114 cases, the cases were composed of 54 carcinomas, 40 borderline tumors, 12 benign tumors and 8 normal control ovarian tissues. Abnormal nucleocytoplasmic expression of β-catenin was found in 4 endometrioid carcinomas. The nuclear expression of β-catenin was found especially in the components of the endometrioid carcinoma (28.6%, P<0.05). Wnt 1 was overexpressed in all 9 clear cell carcinomas, but not frequent in the other types of malignant tumors (P<0.05). We found a statistically significant correlation between β-catenin nuclear localization and endometrioid carcinomas. And we found a significant correlation between Wnt 1 expression and clear cell carcinomas.
Conclusion: It does not seem that Wnt 1 over expression directly provoke the nuclear localization of β-catenin. But, deregulation of β-catenin and Wnt 1 may play a role in the pathogenesis of ovarian epithelial carcinogenesis of endometriod carcinoma and clear cell carcinoma. Evaluating this avenue of regulation of β-catenin and Wnt protein in ovarian epithelial carcinoma may provide a new direction for early diagnosis and treatment in ovarian epithelial carcinoma and provide opportunities for making a certain biomarkers.
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KEYWORD
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Epithelial ovarian carcinoma, Wnt 1, β-catenin, Immunohistochemical staining
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